Major trends that are draining people from the Wheatbelt are globalisation of the economy (and its associated global urban culture) and coastalisation based on lifestyle preferences. A focus on Wheatbelt towns in partnership with the adjacent global city is needed to reverse the decline. It will require a new quality of life attraction similar to that drawing people to the coast, a stronger sense of place, and greater social diversity. It will also require tapping of new global city sustainability obligations through partnerships between the city and its bioregion on issues of biodiversity, new bioindustries, and new water regimes, and clear planning to contain sprawl in the city and coasts. Hope for rejuvenation can be provided through the example of inner city areas, which suffered similar problems of decline, and reversed them over a 30-year period.