Attitudes toward Muslim Americans have been largely understudied in the psychological field. It is important to identify negative attitudes that may be present in particular situations for Muslim Americans in order to better understand and adapt to situations in which negative attitudes are expressed. For this study, 208 subjects (170 females and 38 males) from a California State University campus were recruited; the study explored situational attitudes toward Muslim Americans within the context of social desireability and universal orientation. Contrary to expectations, negative attitudes appeared to be specific rather than global. Implications of the study findings for Muslim American mental health and prevention/ intervention programs are discussed.