The All of Us Research Program is a historic effort to gather data over many years from one million or more people living in the United States, with the ultimate goal of accelerating research and improving health.
Unlike research studies that are focused on a specific disease or population, All of Us will serve as a national research resource to inform thousands of studies, covering a wide variety of health conditions.
Researchers will use data from the program to learn more about how individual differences in lifestyle, environment, and biological makeup can influence health and disease.
Participants may be able to learn more about their own health and contribute to an effort that may advance the health of generations to come.
What makes the All of Us Research Program unique?
Size: 1 million or more participants
Diversity: participants reflect the country’s rich diversity, including communities historically underrepresented in biomedical research •
Scope: richness of information—clinical, biological, sociobehavioral, geographic, environmental, etc.
Duration: longitudinal (lifelong): ongoing data/sample collection, in partnership with participants
Accessibility: data available under agreed-upon terms to researchers from all sectors, including citizen scientists
The All of Us Research Program Protocol provides a detailed look at the program’s plans for building a robust research resource of data from one million or more participants reflecting the diversity of the United States.
A protocol is a scientific document with in-depth plans for a specific research effort. It can help researchers explain what they want to learn and how they’ll carry out their work.
Although the All of Us Protocol is written for researchers, it may be of interest to others. It has a wealth of information about the program, from who can join and what data All of Us will collect to how the program will protect that data and who will be able to access it.
The All of Us Protocol is revised periodically as the program makes updates and adds new features.