Five years on from the announcement of the Australian Government’s Boosting Dementia Research Initiative and with evidence of a significant boost underway, this revision of the 2017 Strategic Roadmap for Dementia Research and Translation takes advantage of emerging strengths and new knowledge to deliver greater focus to, and impact from, the Australian dementia research effort. The need to address all aspects of the challenge continues to be recognised. Increased emphasis and priority is placed on improving outcomes for Aboriginal and Torres Strait Islander Australians, and on the need to retain and develop the new research capacity introduced to the sector.