Journal article

TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice

18 Aug 2015
Description

Consumption of capsaicin (found in chilli) may be able to prevent overeating through an action on nerves in the stomach, according to this report.

Abstract

Within the gastrointestinal tract vagal afferents play a role in control of food intake and satiety signalling. Activation of mechanosensitive gastric vagal afferents induces satiety. However, gastric vagal afferent responses to mechanical stretch are reduced in high fat diet mice. Transient receptor potential vanilloid 1 channels (TRPV1) are expressed in vagal afferents and knockout of TRPV1 reduces gastro-oesophageal vagal afferent responses to stretch. We aimed to determine the role of TRPV1 on gastric vagal afferent mechanosensitivity and food intake in lean and HFD-induced obese mice.

Publication Details
Identifiers: 
DOI: 
10.1371/journal.pone.0135892
Published year only: 
2015
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