The role of SLC2A9 Variants in Hyperuricemia and Gout

Gout is a debilitating arthritis caused by elevated levels of serum urate in the blood (hyperuricemia). The prevalence of gout is on the rise worldwide with particularly high rates of the disease present in Māori and Pacific populations in New Zealand (9.3-13.9% of Māori men...

The genetic basis of lipoprotein(a) variation in the Māori and Pacific populations

Lipoprotein(a) [Lp(a)] is a plasma lipoprotein, characterised by an apo(a) molecule bound via a disulphide bond to apoB of a low density lipoprotein- (LDL-) like particle. Elevated Lp(a) levels are a well established risk factor for development of atherosclerosis. Intriguingly, there is enormous inter-individual variation...

Past, Present and Future: Investigations into the history and possible causes of genetic predisposition to metabolic disorders in Pacific populations

Many indigenous Pacific populations have been observed to have a high prevalence of Type 2 Diabetes and Gout. While lifestyle factors are likely to contribute, there is evidence to suggest that there is a hereditary contribution to these diseases.

Lipoproteins and Hyperlipoproteinemia: Links to Gout

Gout and cardiovascular disease are both complex and multi-factorial with genetic predisposition and environmental triggers. Not only do both have high co-morbidity with other metabolic conditions, gout patients have high risk for cardiovascular events. Māori and Pacific populations have high risk for both gout and...

Testing the Vitamin D3 metabolic gene variants for association with gout in the New Zealand case-control sample-sets

Gout is a common disease caused by immune response to monosodium urate (MSU) crystal deposition in articular or periarticular tissues and in the renal tract after chronic hyperuricemia (uric acid levels exceeding 7mg/dL). Gout generally progresses in three clinical stages: asymptomatic hyperuricemia (elevated serum urate...

Investigation of the Genetic Link Between the Metabolic Diseases Gout and Type 2 Diabetes

Gout is associated with various co-morbidities including insulin resistance and type 2 diabetes. Gout and type 2 diabetes are strongly linked to the individual components of metabolic syndrome. There may be shared pathogenic pathways between gout and type 2 diabetes in which insulin resistance, obesity...