Gout is associated with various co-morbidities including insulin resistance and type 2 diabetes. Gout and type 2 diabetes are strongly linked to the individual components of metabolic syndrome. There may be shared pathogenic pathways between gout and type 2 diabetes in which insulin resistance, obesity, hypertension and hyperuricaemia play a central role.Genetic and environmental factors...

Lipoprotein(a) [Lp(a)] is a plasma lipoprotein, characterised by an apo(a) molecule bound via a disulphide bond to apoB of a low density lipoprotein- (LDL-) like particle. Elevated Lp(a) levels are a well established risk factor for development of atherosclerosis. Intriguingly, there is enormous inter-individual variation in plasma Lp(a) concentration, with up to 69% of this...

Many indigenous Pacific populations have been observed to have a high prevalence of Type 2 Diabetes and Gout. While lifestyle factors are likely to contribute, there is evidence to suggest that there is a hereditary contribution to these diseases.

Gout and cardiovascular disease are both complex and multi-factorial with genetic predisposition and environmental triggers. Not only do both have high co-morbidity with other metabolic conditions, gout patients have high risk for cardiovascular events. Māori and Pacific populations have high risk for both gout and cardiovascular disease. The general aim of this study was to...

Gout is a debilitating arthritis caused by elevated levels of serum urate in the blood (hyperuricemia). The prevalence of gout is on the rise worldwide with particularly high rates of the disease present in Māori and Pacific populations in New Zealand (9.3-13.9% of Māori men and 14.9% of Pacific Island men affected). Genetic and environmental...