This theory paper probes the intersections of Lean, Mass Production and conventional Construction, Lean Construction, the Simple Framework for Integrating Project Delivery model, and Virtual Design and Construction (VDC). The authors argue that Toyota recognized that integration was necessary to achieve the goal of global optimization in design and production and that this imperative confronts Lean Construction today. They briefly describe the Simple Framework for Integrating Project Delivery as a system model to achieve the high level of integration required to deliver a valuable, high-performing building. Then they focus on how VDC fits within and enables the Simple Framework model, explaining each element of VDC and how project teams can leverage it to consistently deliver high-performing buildings.