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This report offers in-depth analysis into the challenges and potential presented by automation and AI in health care and highlights wider implications for the future, setting out considerations for policymakers and the NHS. As well as describing some of the most promising areas of application of automation and AI to health care, the report also explores the challenges, constraints and practical considerations for making the most of automation and AI. The report goes beyond simply considering their potential, to engaging with what it will take to realise the long-term benefits for patients, the public and NHS staff.